NMImETIC NanoBone

Mechanism of action

NMImETIC NanoBone is the first commercial synthetic osteoinductive product in the world in which two mineral and organic phases are in nano-scale. Its organic and mineral phase mimics the structure of natural bone. It is a product, composed of NMImETIC Peptide Nanofibers D (Peptide vial), a synthetic anti-inflammatory, angiogenic, and osteogenic self-assembling peptide nanofibers and nanoceramics (Green Glass Vial), acting as a scaffold. The part of peptide vial is US PATENT US10485895B2. The product is free from surfactants and toxic agents, and since it is entirely synthetic, there is no risk of contamination from a biological source. When NMImETIC NanoBone interacts with bone, it creates a three-dimensional scaffold that fills cracks and repairs defects. Upon contact with bone, it activates the bone surface, exposing bone biomolecules on the bone surface, stimulating angiogenesis and strong bone regeneration. The results of the clinical trial showed that the bone repair has been done significantly within 3 months, which can significantly reduce the toothless period of the implant patients. On the other hand, this product is radiolucent and does not create false positive results in radiography like allografts and xenografts available in the market, and the process of treating patients without open surgery can be followed.

Accelerate your bone healing journey with NMImETIC NanoBone. Its innovative formula promotes enhanced bone growth, achieving 100%  bone regeneration in a mere 2.5 months. This surpasses the performance of leading alternatives like NMImETIC Swelling NanoBone Powder (TBMT, Iran; 63.49%), Osteon II (Genoss, South Korea; 40.97%), NanoBone (Artoss, Germany; 36.20%), and Allograft (Iran; 24.59%), making it the ideal choice for faster and more effective bone healing.

Application

NMImETIC NanoBone as a scaffold containing synthetic angiogenic, anti-inflammatory, and osteogenic self-assembling peptide nanofibers and nanoceramics enhance bone regeneration through the biological motifs within self-assembling peptide nanofibers and spherical nanoceramics. The biocompatible and biodegradable bone scaffold accelerates bone healing. It is used in patients with damaged bones in areas lacking mechanical loading, such as craniofacial defects.

• Socket Preservation
• Ridge Augmentation
• Bone fracture healing
• Craniofacial reconstruction
• Spinal fusion surgeries
• Filling bone voids and defects in orthopedic surgeries
• Dental implant procedures for stabilizing artificial teeth
• Enhancing bone support in joint replacement surgeries
• Correcting bone deformities
• Regenerating bone in periodontal treatments
• Strengthening bone in spinal fusion procedure

Advantages

• Osteoinductive
• Being free from the risk of contamination from a biological source
• Free from surfactants and toxic agents
• Robust bone repair
• Formation of nanofibers at the site
• Usability in narrow spaces, effective coverage of uneven surfaces
• Very low radiographic opacity compared to allografts and other products available in the market.
• Biodegradable and Biocompatible (ISO 10993)

Ingredients

NMImETIC Peptide Nanofibers D

• Self-assembling peptide nanofibers and peptides      0.1%
• Pyrogen free distilled water                                           99.9%

NMImETIC Swelling NanoBone Powder

Volume (ml)

• 0.25
• 0.5
• 1
• 1.5